Place of cytology in the diagnosis of systemic mastocytosis: A case report

Mastocytosis is a heterogeneous group of rare diseases related to the clonal, neoplastic proliferation morphologically and immunophenotypically abnormal mast cells, that accumulate in one or more organ systems. Their pathophysiology dominated by activating mutations C-Kit (Stem Cell Factor receptor). Several pathological forms have been described ranging from isolated cutaneous mastocytosis affecting mainly children, aggressive systemic adults with bone marrow involvement. According WHO 2016 classification hematological malignancies, appear as new entity "myeloid neoplasms acute leukemias" combines cytology (abnormal cells) other genetic molecular criteria. We describe through this observation practical side diagnostic orientation serious, underestimated pathology.